Figure 3.

Central nervous system pathology in mice that had signs of neurologic involvement and succumbed to infection with bim_Bm and bim_Bp Burkholderia pseudomallei isolates. Evidence of central nervous system pathology was demonstrated in these mice. Inflammatory infiltrates were prominent in trigeminal nerve branches and ganglion (original magnification ×400) (A) and in the olfactory bulb (original magnification ×200) (B). Cranial meningitis (C) and spinal (D) meningitis were observed, often with involvement of underlying parenchyma (original magnification ×400). Microabscesses were frequently observed in cerebral cortex (original magnification ×100) (E), brainstem (not shown) and cerebellum (not shown) of mice that had neurologic symptoms and succumbed to infection.