Table 3.
Effect of pretreatment with vehicle or clorgyline (0.3 mg/kg) on the concentration of 5-MeO-DMT in plasma
| Time (min)1 | Vehicle2 | Clorgyline2 | Tarone-Ware Test | ||
|---|---|---|---|---|---|
| ng/mL | nM | ng/mL | nM | ||
| 20 | 52.7±11.8 (0) | 241.6±54.1 | 78.1±9.5 (0) | 357.8±43.7 | χ2 (1, N=10) = 2.83, p=0.093) |
| 30 | 29.2±6.4 (0) | 133.8±29.4 | 62.0±6.6 (0) | 284.0±30.0 | χ2 (1, N=10) = 9.04, p=0.003) |
| 40 | 12.6±4.8 (0) | 57.6±22.1 | 42.0±9.2 (0) | 192.4±42.0 | χ2 (1, N=10) = 5.48, p<0.02) |
| 50 | 3.5±1.7 (1) | 15.8±7.6 | 23.5±5.0 (0) | 107.7±22.8 | χ2 (1, N=10) = 6.28, p<0.02) |
| 60 | 0.6±0.5 (4) | 2.7±2.3 | 15.1±2.1 (0) | 69.2±9.6 | χ2 (1, N=10) = 5.00, p<0.03) |
| 70 | 0±0 (5) | 0±0 | 10.1±4.5 (1) | 46.3±20.6 | – – |
Values are listed as mean±SEM.
1
Interval between injection of 5-MeO-DMT and collection of plasma.
2
The number of left censored values (values below the LOD) is listed in parentheses. Helsel’s Robust Method was used to estimate the mean and variance in cases with 1–3 censored values; simple substitution (null values) was used in cases with ≥4 censored values.