Table I.

Correlation of clinicopathological variables with RECK MI in esophageal squamous cell carcinoma.

Variable	n	ΔMI ≤0.16 (n=151)	ΔMI >0.16 (n=159)	Odds ratio (95% CI)	P-valuea
Gender					0.092
Male	180	95	85	1.48 (0.94–2.33)
Female	130	56	74
Age (years)					0.965
≥60	170	83	87	1.01 (0.65–1.58)
<60	140	68	72
Size (cm)					0.387
<3	172	80	92	0.82 (0.52–1.29)
≥3	138	71	67
Tobacco					0.062
Yes	168	90	78	1.53 (0.98–2.40)
No	142	61	81
Alcohol					0.056
Yes	147	80	67	1.55 (0.99–2.42)
No	163	71	92
Depth of invasion					0.079
T1–2	224	108	116	0.93 (0.57–1.53)
T3–4	86	43	43
AJCC stage					<0.0001b
I–II	125	78	47	2.55 (1.60–4.06)
III–IV	185	73	112
Lymph node metastasis					0.001b
N0–1	148	87	61	2.18 (1.39–3.44)
N2–3	162	64	98
Distant metastasis					0.513
M0	251	120	131	0.83 (0.47–1.46)
M1	59	31	28
Differentiation					0.806
G1	88	41	47
G2	142	72	70
G3	80	38	42

^aComparisons were performed using Pearson's χ² test.

^bP<0.05. RECK, reversion-inducing cysteine-rich protein with kazal motif; MI, methylation index; CI, confidence interval; AJCC, American Joint Committee on Cancer.