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. 2017 Feb 14;13(4):2471–2476. doi: 10.3892/ol.2017.5741

Figure 1.

Figure 1.

MRP1 protein expression in multidrug resistance colorectal cancer cells. Representative western blot of MRP1 protein expression in (A) Colo205/5-FU and (B) HCT-8/5-FU cells for five independent samples. Lanes: 1, parental cells; 2, 5-FU-resistant cells; 3, 2 µg shRNA-transfected 5-FU resistant cells; 4, 4 µg shRNA-transfected 5-FU resistant cells; 5, 6 µg shRNA-transfected 5-FU resistant cells. The expression of MRP1 markedly diminished following treatment with shMRP1. (C) Results of relative MRP1 protein expression in Colo205/5-FU and in HCT-8/5-FU cells. n=3/group. Results are presented as the mean ± standard error. MRP1, multidrug resistance associated protein 1; shRNA, short hairpin RNA; shMRP1, shRNA targeting MRP1; 5-FU, 5-fluorouracil.