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Apoptosis of multidrug resistance colorectal cancer cells following shMRP1 transfection. The percentage of cell apoptosis following shMRP1 transfection for (A) Colo205/5-FU cells and (B) HCT-8/5-FU cells. (C) Apoptosis was significantly increased in hMRP1-transfected 5-FU resistant cells compared with their untransfected counterparts. n=3/group. *P<0.001. shMRP1, short hairpin RNA targeting multidrug resistance associated protein 1; PI, propidium iodide; 5-FU, 5-fluorouracil.
