Figure 3.

Short hairpin RNA-induced MRP1 knockdown inhibits colorectal cancer tumor growth in BALB/c nude mice. (A) Tumor volume was measured using a caliper and the measurement of tumor volume in the 2 groups was displayed on the 15th day following shMRP1-transfected Colo205/5-FU cell injection. (B) On the 9, 12 and 15th day tumor volume in the shMRP1-transfected Colo205/5-FU cell-injected group was significantly lower compared with that in the Colo205/5-FU cell-injected group. n=4/group. *P<0.001 vs. untransfected cell-injected mice. shMRP1, short hairpin RNA targeting multidrug resistance associated protein 1; 5-FU, 5-fluorouracil.