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FFJ-3 reduces the mitochondrial membrane potential of cancer cells. Changes in mitochondrial membrane potential were detected with Rh123 staining. A significant increase in Rh123 fluorescence intensity in HepG2, A549 and MCF-7 cells following treatment with 12–36 µM FFJ-3 was demonstrated. *P<0.05, **P<0.01 vs. the untreated control group. Rh123, Rhodamine 123.
