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. 2017 Feb 22;13(4):2607–2614. doi: 10.3892/ol.2017.5761

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — FFJ-3 increases the ratio of Bax/Bcl-2 expression and activates the caspase-3 cascade in cancer cells. Changes in Bcl-2, Bax, caspase-3, cleaved caspase-3, PARP and cleaved PARP expression were examined in HepG2, A549 and MCF-7 cells following FFJ-3 treatment for 48 h. (A) Western blot analysis of Bax and Bcl-2 protein expression following treatment with FFJ-3. (B) FFJ-3 significantly increased the ratio of Bax/Bcl-2 protein expression. (C) Western blot analysis of caspase-3, cleaved caspase-3, PARP and cleaved PARP protein expression following treatment with FFJ-3. (D) FFJ-3 activates the caspase-3 cascade in cancer cells. *P<0.05, **P<0.01 compared with the untreated control group. Bcl-2, B-cell lymphoma 2; Bax, Bcl-2 associated X apoptosis regulator; PARP, poly (ADP-ribose) polymerase; MFI, mean fluorescence intensity.