Table III.
Association between clinicopathological factors and high exosomal miR-21 expression.
| Factors | No. of patients (n=195) | miR-21 high (n=88) | Positive rate, % | P-value |
|---|---|---|---|---|
| Gender | 0.65 | |||
| Male | 112 | 49 | 43.8 | |
| Female | 83 | 39 | 47.0 | |
| Smoking status | 0.11 | |||
| Non-smokers | 68 | 36 | 52.9 | |
| Smokers | 127 | 52 | 40.9 | |
| Tumor size, cm | 0.02 | |||
| <3 | 136 | 54 | 39.7 | |
| ≥3 | 59 | 34 | 57.6 | |
| Lymph node metastasis | 0.10 | |||
| n (−) | 148 | 59 | 39.9 | |
| n (+) | 47 | 29 | 61.7 | |
| Lymphatic invasion | 0.29 | |||
| Ly (−) | 153 | 66 | 43.1 | |
| Ly (+) | 42 | 22 | 52.4 | |
| Venous invasion | 0.56 | |||
| V (−) | 122 | 57 | 46.7 | |
| V (+) | 73 | 31 | 42.5 | |
| Histological type | 0.87 | |||
| Adenocarcinoma | 134 | 60 | 44.8 | |
| Squamous cell carcinoma | 53 | 25 | 47.2 | |
| Others | 8 | 3 | 37.5 | |
| Tumor differentiation | 0.43 | |||
| Well | 91 | 37 | 40.7 | |
| Moderate | 74 | 35 | 47.3 | |
| Poor | 30 | 16 | 53.3 | |
| TNM stage | 0.03 | |||
| I, II | 163 | 68 | 41.7 | |
| III | 32 | 20 | 62.5 |
miR/miRNA, microRNA; TNM, tumor-node-metastasis.