Table IV.
Association between clinicopathological factors and high exosomal miR-4257 expression.
| Factors | No. of patients (n=195) | miR-4257 high (n=54) | Positive rate, % | P-value |
|---|---|---|---|---|
| Gender | ||||
| Male | 112 | 29 | 25.9 | 0.51 |
| Female | 83 | 25 | 30.1 | |
| Smoking status | ||||
| Non-smokers | 68 | 20 | 29.4 | 0.60 |
| Smokers | 127 | 34 | 26.8 | |
| Tumor size, cm | ||||
| <3 | 136 | 35 | 25.7 | 0.35 |
| ≥3 | 59 | 19 | 32.2 | |
| Lymph node metastasis | ||||
| n (−) | 148 | 36 | 24.3 | 0.06 |
| n (+) | 47 | 18 | 38.3 | |
| Lymphatic invasion | ||||
| Ly (−) | 153 | 37 | 24.2 | 0.04 |
| Ly (+) | 42 | 17 | 40.5 | |
| Venous invasion | ||||
| V (−) | 122 | 35 | 28.7 | 0.69 |
| V (+) | 73 | 19 | 26.0 | |
| Histological type | ||||
| Adenocarcinoma | 134 | 47 | 35.1 | 0.02 |
| Squamous cell carcinoma | 53 | 5 | 9.4 | |
| Others | 8 | 2 | 25.0 | |
| Tumor differentiation | ||||
| Well | 91 | 26 | 28.6 | 0.97 |
| Moderate | 74 | 20 | 27.0 | |
| Poor | 30 | 8 | 26.7 | |
| TNM stage | ||||
| I, II | 163 | 38 | 23.3 | <0.01 |
| III | 32 | 16 | 50.0 |
miR/miRNA, microRNA; TNM, tumor-node-metastasis.