Table II.
Risperidone reversed the role that MK-801 plays regarding the spatial object recognition ability changes in rats (means ± SD).
| Group | Number of rats | Activity distance during the habituation phase (m) | Exploration time during the familiarisation phase (s) | Exploration time for the objects in new locations (s) | Exploration time for objects in old locations (s) | PI of the objects in new locations (%) |
|---|---|---|---|---|---|---|
| Control | 8 | 37.54±1.84 | 62.20±6.79 | 42.78±5.23 | 18.43±2.24d | 68.53±4.28c |
| MK-801 | 8 | 37.21±3.13 | 71.33±6.63 | 34.99±4.58 | 33.83±4.47 | 50.78±3.99a |
| Risperidone | 8 | 33.97±3.58 | 54.65±4.15 | 40.23±4.85 | 19.68±2.05d | 66.19±3.46c |
| Intervention | 8 | 36.17±2.38 | 64.21±7.95 | 41.24±6.69 | 21.23±2.52d | 64.95±3.31b |
A two-factor analysis of variance and the LSD test compared with the control group
a
P<0.01, and compared with the model group
b
P<0.05
c
P<0.01. A paired samples t-test regarding the exploration time for objects in new and old locations
d
P<0.01. SD, standard deviation; MK-801, dizocilpine maleate; PI, preference index; LSD, least significant difference.