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The proposed mechanism for oridonin-induced G2/M arrest and apoptosis in prostate cancer cells. PI3K, phosphoinositide 3-kinase; MDM2, murine double minute 2; Bcl-2, B-cell lymphoma 2; Bax, Bcl-2-associated X protein; CDK1, cyclin-dependent kinase 1; PARP, poly (ADP-ribose) polymerase.
