Table III.

Results of the univariate and multivariate analyses of selected factors for PFS in all patients.

	Univariate		Multivariate
Variable	HR (95% CI)	P-value	HR (95% CI)	P-value
Gender (male, vs. female)	0.624 (0.383–1.017)	0.059
Age (≤64, vs. >64 years)	0.929 (0.593–1.456)	0.749
Smoking status (never, vs. current/former)	2.012 (1.254–3.229)	0.004	1.172 (0.682–2.012)	0.566
Histology (adenocarcinoma, vs. squamous)	2.168 (1.273–3.695)	0.004	1.111 (0.670–1.844)	0.747
Histological differentiation (well, vs. poor)	0.873 (0.535–1.424)	0.586
Lymph node metastasis (yes, vs. no)	2.576 (1.493–4.443)	0.001	2.400 (1.353–4.257)	0.003
Distant metastasis (yes, vs. no)	1.294 (0.824–2.032)	0.264
EGFR (mutated, vs. wild type)	0.238 (0.139–0.409)	<0.001	0.284 (0.150–0.537)	<0.001
Estrogen receptor-β (positive, vs. negative)	1.924 (1.197–3.092)	0.007	1.111 (0.670–1.844)	0.684
P53 (positive, vs. negative)	1.102 (0.698–1.738)	0.678

EGFR, epidermal growth factor receptor; HR, hazard ratio; CI, confidence interval.