Table II.

Association of various candidate prognostic factors with overall survival of 180 glioma patients, as evaluated by Cox regression analysis.

		Univariate analysis		Multivariate analysis
Variable	Groups	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value
Age, years	<50 vs. ≥50	1.082 (0.568–1.966)	NS	–	–
Gender	Male vs. female	1.021 (0.553–1.922)	NS	–	–
Tumor size, cm	<5 vs. ≥5	1.168 (0.689–2.139)	NS	–	–
Tumor location	Supratentorial vs. subtentorial	1.026 (0.581–1.938)	NS	–	–
Karnofsky performance scale	<90 vs. ≥90	2.689 (1.291–5.693)	0.010	2.043 (0.896–4.338)	0.030
WHO grade	I–II vs. III–IV	3.625 (1.673–7.932)	<0.001	3.267 (1.392–6.581)	0.001
Tumor recurrence	Absent vs. present	2.018 (0.819–3.983)	NS	–	–
LKB1 expression	Absent vs. present	3.348 (1.397–7.026)	<0.001	3.022 (1.002–6.016)	0.001

WHO, World Health Organization; LKB1, liver kinase B1; NS, no significance; CI, confidence interval.