Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Apr 24;11:115. doi: 10.3389/fncel.2017.00115

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 Duménieu, Oulé, Kreutz and Lopez-Rojas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Molecular mechanisms allowing segregated expression of the dendritic Kv4.2 and Kv2.1 channels. (A) Sorting and trafficking of Kv4.2 and Kv2.1 channels. Association of Kv4.2 channel with auxiliary protein K⁺ channel Interacting Protein (KChIP) targets the channel to the cell surface. Kif17 ensures microtubule-based transport whereas myosin Va is used for actin-based transport of Kv4.2 channel on proximal dendrites and spines. Myosin IIb transports Kv2.1 to the somatodendritic compartment. (B) Intrinsic motifs, posttranslational regulations and binding partners regulating Kv4.2 surface expression. (C) Intrinsic motifs, posttranslational regulations and binding partners regulating Kv2.1 cluster formation and function.