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. 2017 Feb 1;13(3):1990–1996. doi: 10.3892/ol.2017.5663

Figure 3.

Figure 3.

PT93 suppresses the expression of MMP-2/9 and activity of T98G and U251 cells. (A) Inhibition of MMP-2/−9 activity induced by PT93 in T98G cells at increasing concentrations. Extracellular activities of MMP-2/−9 were estimated by gelatin zymography analysis. There were significant differences of MMP-9 activity at concentrations of 3 and 10 µM compared with the control. At 3 and 10 µM, MMP-2 activity was markedly reduced. (B) Inhibition of MMP-2/−9 activity induced by PT93 in U251 cells at increasing concentrations. Extracellular activities of MMP-2/−9 were estimated by gelatin zymography analysis. There were significant differences in MMP-2/−9 activity at 1, 3 and 10 µM compared with control. (C) Intracellular MMP-2/−9 expression was measured by western blot analysis in T98G cells. MMP-2/−9 expression was reduced as PT93 concentration increased. There were significant differences in MMP-2/−9 activity at 1, 3 and 10 µM compared with the control. **P<0.01 and ***P<0.001 compared with control. CT, control; MMP, matrix metalloproteinases.