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Lentivirus-mediated HMGA1 knockdown inhibited SW579 cell invasion and migration. (A) Lentivirus-mediated HMGA1 knockdown significantly inhibited thyroid cancer SW579 cell invasion. ***P<0.001. (B) Lentivirus-mediated HMGA1 knockdown significantly inhibited thyroid cancer SW579 cell migration, **P<0.01. (C) Western blotting assay showed that lentivirus-mediated HMGA1 knockdown decreased MMP-2 expression, and increased E-cadherin expression in SW579 cells.
