Table I.
Association between Sphk1 expression and the clinicopathological features of HCC.
| Sphk1 expression | ||||
|---|---|---|---|---|
| Variable | No. of cases | High | Low | P-value |
| Gender | NS | |||
| Male | 71 | 52 | 19 | |
| Female | 56 | 41 | 15 | |
| Age | NS | |||
| ≥50 years | 66 | 53 | 13 | |
| <50 years | 61 | 40 | 21 | |
| Tumor size | 0.015 | |||
| ≥5 cm | 78 | 63 | 15 | |
| <5 cm | 49 | 30 | 19 | |
| HBsAg | NS | |||
| Positive | 62 | 48 | 13 | |
| Negative | 65 | 44 | 21 | |
| Histological differentiation | 0.018 | |||
| Well/Moderate | 81 | 65 | 16 | |
| Poor | 46 | 28 | 18 | |
| AFP | NS | |||
| >400 ng/ml | 76 | 56 | 20 | |
| ≤400 ng/ml | 51 | 37 | 14 | |
| Tumor stage | 0.009 | |||
| I–II | 58 | 36 | 22 | |
| III–IV | 69 | 57 | 12 | |
Sphk1, sphingosine kinase 1; NS, not significant; HBsAg, hepatitis B virus surface antigen; AFP, α-fetoprotein.