Table II.

Univariate analysis and multivariate analysis of overall survival.

	Univariate analysis			Multivariate analysis
Variables	HR	95% CI	P-value	HR	95% CI	P-value
Sphk1	2.150	1.051–4.395	0.019	2.021	1.011–4.037	0.017
Age	1.025	0.522–2.014	0.424	–	–	–
Gender	1.116	0.563–2.212	0.375	–	–	–
Tumor size	2.204	1.026–4.737	0.036	1.883	0.960–3.693	0.031
HBsAg	1.583	0.765–3.275	0.071	–	–	–
Histological differentiation	2.011	0.960–4.213	0.038	1.851	0.936–3.659	0.033
AFP	1.316	0.651–2.664	0.120	–	–	–
Tumor stage	2.087	1.009–4.316	0.026	1.848	0.935–3.654	0.034

Sphk1, sphingosine kinase 1; HR, hazard ratio; CI, confidence index; HBsAg, hepatitis B virus surface antigen; AFP, α-fetoprotein.