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. 2017 Apr 5;50(5):1491–1500. doi: 10.3892/ijo.2017.3953

Figure 1.

Figure 1

Expression of Psoriasin in pancreatic cancer and pancreatic cancer cell lines with altered Psoriasin expression. (A) Reduced expression of Psoriasin was seen in a cohort of 45 pancreatic ductal adenocarcinomas in comparison with its expression in the paired adjacent normal pancreatic tissues (GDS4336) (26). (B) An elevated expression of Psoriasin was seen in metastases of pancreatic cancer compared with its expression in primary tumours (GSE71729) (25). (C) Psoriasin and RAGE transcripts were detected in PANC-1, AsPC-1 and MIA-PaCa-2 cell lines using conventional PCR. Knockdown and overexpression of Psoriasin were performed using anti-Psoriasin ribozyme transgenes and a recombinant plasmid vector carrying full-length human Psoriasin coding sequence, respectively. The altered expression of Psoriasin in the transfected pancreatic cancer cell lines (MIA-PaCa-2 and PANC-1) was verified using conventional PCR (D) and real-time PCR (E). *p<0.05, **p<0.01.