Figure 1.

miR-134 was decreased in MDR lung adenocarcinoma cells. (A) The expression levels of miR-134 in A549 and A549/CDDP cells were examined by RT-qPCR. U6 was used as a control. (B) A549/CDDP cells were transfected with miR-134 mimics, while (C) A549 cells were transfected with miR-134 inhibitors. The expression of miR-134 was detected by RT-qPCR at 48 h following transfection. (D) Relative expression levels of miR-134 were detected in ‘insensitive’ (n=17) and ‘sensitive’ (n=13) lung adenocarcinoma tissues via RT-qPCR. Data were obtained from three independent experiments (**P<0.01). miR, microRNA; RT-qPCR, reverse transcription-quantitative polymerase chain reaction; CDDP, cisplatin; NC, negative control.