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Manhattan plot for P-values of allele frequencies in the exome-wide association study (EWAS) of aortic aneurysm. The P-values (y-axis) are shown as −log10(P) with respect to the physical chromosomal position of the corresponding single nucleotide polymorphism (SNP) (x-axis). The three SNPs ultimately found to be significantly associated with true aortic aneurysm (EGFLAM, SPATC1L) or dissecting aneurysm (RNASE13) are indicated.
