Table IV.
Correlation of single nucleotide polymorphisms (SNPs) to true aortic aneurysm as determined by multivariable logistic regression analysis.
| SNP | Dominant
|
Recessive
|
Additive 1
|
Additive 2
|
|||||
|---|---|---|---|---|---|---|---|---|---|
| P-value | OR (95% CI) |
P-value | OR (95% CI) |
P-value | OR (95% CI) |
P-value | OR (95% CI) |
||
| rs143881017 | C/T (R140H) | 0.2899 | ND | 0.2899 | ND | ||||
| rs5751416 | G/A | 0.0448 | 0.73 (0.54–0.99) | 0.1221 | 0.1030 | 0.0663 | |||
| rs142154818 | G/A (T1062M) | 0.2214 | 0.8209 | 0.2154 | 0.8231 | ||||
| rs13118 | T/A | 0.0253 | 1.51 (1.05–2.14) | 0.6076 | 0.0167 | 1.57 (1.09–2.23) | 0.6967 | ||
| rs5030685 | A/G (V743A) | 0.0779 | 0.7314 | 0.0667 | 0.7333 | ||||
| rs1465567 | T/C (W229R) | 0.0014 | 1.63 (1.21–2.21) | 0.6670 | 0.0014 | 1.66 (1.22–2.27) | 0.2911 | ||
| rs7253812 | C/A | 0.0122 | 1.47 (1.09–1.99) | 0.2265 | 0.0032 | 1.60 (1.17–2.18) | 0.5864 | ||
| rs7150931 | T/C | 0.7329 | 0.0431 1.45 | (1.01–2.04) | 0.2737 | 0.2350 | |||
Multivariable logistic regression analysis was performed with adjustment for age, gender and the prevalence of hypertension. Based on Bonferroni's correction, P-values of <0.0016 (0.05/32) were considered statistically significant and are shown in bold. OR, odds ratio; CI, confidence interval; ND, not determined.