Table IV.
Secretion of IL-12, IL-10, IL-4, IL-17 and IFN-γ by dendritic cells, as determined using a double-antibody sandwich enzyme-linked immunosorbent assay.
| Factor, pg/ml | |||||
|---|---|---|---|---|---|
| Treatment group | IL-12 (P-value) | IL-10 (P-value) | IL-4 (P-value) | IL-17 (P-value) | IFN-γ (P-value) |
| Day 6 without stimulation (control group) | 7.18±2.63 (reference) | 64.42±3.59 (reference) | 49.58±2.84 (reference) | 16.38±6.94 (reference) | 70.12±3.25 (reference) |
| Day 7 without stimulation (group A) | 5.86±3.54 (P=0.632) | 65.23±4.10 (P=0.810) | 50.41±2.94 (P=0.743) | 16.21±6.86 (P=0.977) | 69.25±3.42 (P=0.765) |
| TNF-α-stimulated maturation (group B) | 57.01±12.54 (P=0.003) | 14.33±2.39 (P<0.001) | 8.29±2.05 (P<0.001) | 60.01±5.96 (P=0.001) | 218.69±7.51 (P<0.001) |
| Stimulation by the VNTR1 plasmid (group C) | 46.18±9.93 (P=0.003) | 13.96±2.77 (P<0.001) | 9.17±2.16 (P<0.001) | 68.26±7.01 (P<0.001) | 224.31±7.61 (P<0.001) |
| TNF-α and VNTR1 plasmid co-stimulation (group D) | 52.47±11.26 (P=0.003) | 13.24±2.48 (P<0.001) | 9.53±2.44 (P<0.001) | 61.95±7.12 (P=0.001) | 228.95±7.81 (P<0.001) |
IL, interleukin; IFN-γ, interferon-γ; TNF-α, tumor necrosis factor-α.