Table 1.

Pharmacological manipulations affecting social and repetitive behavior in the BTBR T⁺Itpr3^tf/J mouse.

	Manipulation	Mechanism	Social interaction	Self-grooming	Marble burying	Other tests	Reference
Excitatory/Inhibitory imbalance	2-Methyl-6-(phenylethynyl) pyridine (MPEP)	selective mGluR5 antagonist	=				Silverman et al. 2010a
							Burket et al 2011
						Object location memory	Seese et al. 2014
						MWM Rotarod	Yang et al. 2015
	GRN-529	selective negative allosteric modulator of the mGluR5 receptor	soc sniffing soc appr				Silverman et al. 2012
	D-cycloserine	partial glycineB site agonist targeting NMDAR				Rearing	Burket et al. 2013
	CX1837, CX1739 and CX546	AMPAKINEs	soc sniffing	=		OF = (except for CX546, which caused sedation) CX1837 novel object recognition	Silverman et al. 2013
	CX929	AMPAKINE				Object location memory =	Seese et al. 2014
	Diazepam	positive allosteric modulator of GABAA receptors	soc appr				Pobbe et al. 2011
			under				Defensor et al 2011
						EPM arm entries	Kazdoba et al. 2016
	Diazepam at P15–28					Multi-sensory integration	Gogolla et al. 2014
	Clonazepam		soc appr			Circling OF, EPM activity = Fear memory	Han et al. 2014
	Allopregnanolone					EPM arm entries	Kazdoba et al. 2016
	Ganaxolone		soc sniffing soc appr	=	=	OF, EPM activity
	L-838,417	α2,3 subunit-selective positive allosteric modulator of GABAA receptors	soc appr			Fear memory (short and long term)	Han et al. 2014
	Zolpidem	α1 subunit-selective positive GABAA modulator	soc appr at a high dose			Fear memory (only short term)
	R-baclofen	selective GABAB receptor agonist	soc appr				Silverman et al. 2015
monoaminergic	Risperidone	Qualitatively atypical antipsychotic (5HT1A,B,D,5A,6,7 antagonist, 5HT2A,B,C inverse agonist, D1,2,4,5 antagonist, D3 inverse agonist, α1A,B, 2A,B antagonist, H1,2 inverse agonist)	=				Gould et al. 2011
			=			EPM =	Chadman 2011
						Probabilistic learning	Amodeo et al. 2014
	Fluoxetine	SERT blocker	soc appr		=		Gould et al. 2011
			soc appr			EPM =	Chadman 2011
	Buspirone	5HT1A receptor partial-agonist	soc appr		=		Gould et al. 2011
	M100907	5HT2A antagonist				Probabilistic learning	Amodeo et al. 2014
							Amodeo et al. 2016a and b
	Citalopram	selective serotonin reuptake inhibitor (SSRI)				Tail suspension	Crowley et al. 2005
	Dietary tryptophan	5HT precursor	soc appr but not soc novelty	=	=		Zhang et al. 2015
	D-amphetamine	Psychostimulant, acting via DA-ergic enhancement in the mesolimbic circuit	duration of soc sniffing				Silverman et al. 2013
	3,4-Methylenedioxym ethamphetamine (MDMA, ecstasy)	Psychostimulant, presynaptic releasing agent of serotonin, norepinephrine, and dopamine				Locomotor activity =	Onaivi et al. 2011
	metamphetamine	Psychostimulant, full agonist of trace amine-associated receptor 1 (TAAR1)
	1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)	Neurotoxin destroying dopaminergic neurons
	(−)-trans-Δ9-tetrahydrocannabi nol	partial agonist activity at the cannabinoid receptor CB1				Spontaneous wheel running
	Acetaminophen (paracetamol)	cannabinoid CB(1) receptor-mediated inhibition of serotonin (5-HT) transmission in the frontal cortex, 5HT agonism	soc appr		=		Gould et al. 2012
	Atomoxetine	noradrenergic reuptake inhibitor				Fear memory	Stapley et al. 2013
cholinergic	Oxotremorine	Muscarinic acetylcholine receptor (mAChR) agonist					Amodeo et al. 2014
	Nicotine	nicotinic acetylcholine receptor (nAChR) agonist	soc appr at low doses	at high doses		OF activity	Wang L et al. 2015
	Donepezil	(AchEI) Acetylocholinester ase inhibitor	soc appr and novelty soc sniffing			Rigidity in T-maze and jammed running wheel	Karvat and Kimchi 2014
other pathways	Chronic intranasal oxytocin	Neuropeptide, OXTR agonist	= soc sniffing in females	=		Juvenile social interaction = Fear memory =	Bales et al. 2014
	Rapamycin	mTORC1 inhibitor	soc appr soc sniffing	=			Burket et al. 2014
	histidine, lysine, threonine diet	mTORc1 inhibition	=				Wu et al. 2016
	Sodium butyrate	HDAC inhibitor	soc novelty at low doses	=			Kratsman et al. 2016
	SR1078	retinoic acid receptor-related orphan receptor α (RORα) agonist					Wang et al 2016
	GW7647	Peroxisome proliferator-activated receptor agonist					D’Agostino et al. 2015
	sgp130Fc	IL-6 trans-signaling blocker	soc appr	=			Wei et al. 2016c

soc appr – social approach in the three chambered apparatus

soc novelty – preference for novel mouse in the third phase of three chambered apparatus social approach test

soc sniffing – either during social approach test in the three chambered apparatus or in close dyadic interaction

MWM – Morris Water Maze

OF – Open Field test

EPM – Elevated Plus Maze