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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Neurosci Biobehav Rev. 2017 Mar 11;76(Pt A):154–162. doi: 10.1016/j.neubiorev.2017.01.026

Table 1.

Rodent models associated with the development of binge-eating like behaviors.

Model Species Procedure Eating Outcome Obesity
outcome
Reference
Sham feeding Rat Animals are
fitted with
chronic
fistulas to
drain liquid
food before
entering the
gastrointestin
al tract
Hyperphagia in
brief periods of
time
No
body
weight
gain
Smith et al. 1989
Restriction/Refeedi
ng
Rat access to
palatable diet
is followed by
food
deprivation
cycle
Rebound
hyperphagia of
highly palatable
food upon
refeeding
No
body
weight
gain
Hagan and Moss, 1996
Tail pinch Rat Pinching a
rat’s tail while
measuring
the rat’s food
intake
Increased
intake during
tail pinching
and shortly
afterwards
No
body
weight
gain
Rowland and Antelman, 1976
Shock stress Rat Measurement
of food intake
after
application of
an acute 0.6
mA electric
shock.
Increased daily
consumption of
high palatable
diet when
associated with
food restriction
No
body
weight
gain
Hagan et al. 2002
Limited access Rat/mous
e
Limited
availability of
optional
source of
dietary fat
under non-
food-deprived
conditions.
Increased high
sucrose/fat/mix
ed diet at onset
of access, and
larger fewer
sugary meals
throughout the
access period
Body
weight
gain/
No
body
weight
gain
Avena et al. 2009; King et al., 2016; Wojnicki et al. 2008.
Visible burrow
system
Rat Single
housing after
2 weeks
exposure to
subordination
Hyperphagia
from longer
meals with
longer inter-
meal intervals
Body
weight
gain
Melhorn et al. 2010
in mixed-sex
colonies
occurring in the
recovery post-
stress phase
Chronic social
defeat
Mouse Single
housing after
10 days
subordination
and protected
co-housing
with 10
different
aggressor
mice.
Increased daily
food intake,
unknown meal
pattern
occurring in the
recovery post-
stress phase
Body
weight
gain
Lutter et al. 2008
Chronic
psychosocial stress
Mouse 4 weeks
subordination
and protected
co-housing
with the same
aggressor
mouse.
Hyperphagia
from higher
consumption
rate and
reduced satiety
intervals
Body
weight
gain
Razzoli et al. 2015