Table 3.

Univariate Analysis of Variables Associated with 5-Day Treatment Failure

	Treatment Failure by Day 5		P-value
	No (N=54)	Yes (N=16)
Age, years	52 (49, 60)	50 (45, 52.5)	0.04
Male/Female	38/16	15/1	0.09
Etiology of Liver Disease			0.08
Viral hepatitis alone	8 (15%)	2(12%)
Alcohol liver disease alone	19 (35%)	11 (69%)
Viral and Alcohol	17 (31%)	3 (19%)
Other	10 (19%)	0 (0%)
Previous episodes of variceal hemorrhage	22 (41%)	8 (50%)	0.51
Any Previous Prophylaxis (Beta-Blockers ± Ligation, etc.)	29 (54%)	6 (38%)	0.26
BMI, kg/m^2	25.8 (23.6, 31)	30.6 (21.4, 32.5)	0.18
Admission SBP, mm Hg	113 (102, 127)	109 (98, 129)	0.56
Admission HR, bpm	95 (80, 109)	105 (87, 118)	0.33
Ascites	25 (46%)	11 (69%)	0.16
Hepatic Encephalopathy	12 (22%)	4 (25%)	0.99
Labs at Admission
Hemoglobin, g/dL	10.2 (8.4, 11.7)	9.0 (7.0, 9.6)	0.03
White Blood Cells, 10^9/L	8.9 (6.8, 13.0)	7.5 (5.4, 12.5)	0.34
AST, Units/L	71 (42, 115)	82 (43, 120)	0.89
ALT, Units/L	40 (26, 68)	31 (23, 46)	0.15
Albumin, g/dL	2.8 (2.1, 3.2)	2.0 (1.8, 2.6)	0.01
Total Bilirubin, mg/dL	1.7 (1.1, 3.2)	3.4 (1.2, 5.4)	0.34
Creatinine, mg/dL	0.8 (0.7, 1.1)	1.3 (1.0, 1.7)	0.002
Platelets, 10^9/L	120 (75, 176)	99 (70, 169)	0.49
INR	1.4 (1.3, 1.7)	1.6 (1.4, 2.0)	0.06
Child-Turcotte-Pugh score	8 (7, 10)	10 (8, 12)	0.006
Child-Turcotte-Pugh class % (A/B/C)	23% / 47% / 30%	0% / 40% / 60%	0.03
MELD score	13 (11, 19)	18 (14, 27)	0.03
Active bleeding at endoscopy	14 (26%)	3 (19%)	0.74
Endoscopic band ligation / sclerotherapy	91% / 9%	94% / 12%	0.66
Need for balloon tamponade	2 (4%)	1 (6%)	0.99
Rescue TIPS	2 (4%)	1 (6%)	0.99

Data are expressed as medians (first interquartile, third interquartile) or N (percentage) unless otherwise stated.

BMI, body mass index; AST, aspartate aminotransferase; ALT, alanine aminotransferase; INR, international normalized ratio; MELD, Model for End-Stage Liver Disease; TIPS, transjugular intrahepatic portosystemic shunt; SBP, systolic blood pressure; HR, heart rate