. Author manuscript; available in PMC: 2018 May 1.

Published in final edited form as: Osteoarthritis Cartilage. 2016 Dec 7;25(5):639–646. doi: 10.1016/j.joca.2016.12.003

Table 3.

Logistic regression analyses for the risk of developing symptomatic and radiographic knee OA, during the four year follow up period. GEEs fit to account for the clustering of knees within participants. 57 knees from 30 participants were excluded due to missing data.

Laterality of foot/ankle symptoms	Total number of knees (participants)	No symptomatic knee ROA N (%)	Symptomatic Knee ROA N (%)	Risk for symptomatic knee ROA

				Unadjusted OR (95% CI)	P value	Adjusted^† OR (95% CI)	P value
No symptoms (ref)	1736 (869)	1707 (88.1)	29 (64.4)	1		1
Any side	247 (124)	231 (11.9)	16 (35.6)	4.26 (2.23 to 8.12)	<0.001	3.28 (1.69 to 6.37)	0.0004
Ipsilateral	70 (70)	67 (3.5)	3 (6.7)	2.57 (0.76 to 8.74)	0.131	2.28 (0.70 to 7.37)	0.171
Contralateral	71 (71)	67 (3.5)	4 (8.9)	4.35 (1.61 to 11.74)	0.004	3.08 (1.06 to 8.98)	0.039
Bilateral	106 (53)	97 (5.0)	9 (20.0)	5.38 (2.50 to 11.55)	<0.001	4.02 (1.76 to 9.17)	0.001

OA, osteoarthritis; ROA, radiographic osteoarthritis; OR, odds ratios; CI, confidence intervals.

^†

Adjusted for age, sex, race, BMI, Charlson Comorbidity index (dichotomised) and depression.