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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Environ Toxicol. 2016 Oct 24;32(8):2004–2020. doi: 10.1002/tox.22374

Figure 8. A model for arsenite-induced Nrf2 activation to protect against oxidative damage via the cGMP-PKG signaling pathway in HBE cells.

Figure 8

Arsenite induces oxidative damage while it activates cGMP-PKG signaling pathway by increasing cellular level of cGMP and PKG in HBE cells. This in turn increases the level of Nrf2 which subsequently increases cellular level of GSH and SOD activity, thereby reducing the elevated level of ROS induced by arsenite. This then significantly reduces oxidative DNA damage, chromosomal breakage and lipid peroxidation induced by arsenite.