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. 2017 Jan 20;13(3):851–860. doi: 10.3892/etm.2017.4071

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Copyright: © Zhu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Sub-types of HVA-Ca²⁺ currents identified by application of specific channel blockers. (A) To individually assess various types of calcium channels present in the same cell, 20 µmol/l nifedipine (L-type Ca²⁺-specific channel blocker), 2 µmol/l ω-conotoxin MVIIC (P/Q-type Ca²⁺ channel-specific blocker) and 2 µmol/l ω-conotoxin MVIIA (N-type Ca²⁺ channel-specific blocker) were applied to the bath in sequence when stable currents were reached. (B) Fraction changes of each sub-type (L, N, P/Q) Ca²⁺ channel current over the total HVA-Ca²⁺ peak currents in control, adjacent and axotomized neurons. Values are expressed as the mean ± standard deviation (n=10). *P<0.05 vs. control neurons (ANOVA); ^#P<0.05 regarding axotomized vs. adjacent neurons (ANOVA). HVA, high-voltage activation; ANOVA, analysis of variance; SNL, spinal nerve ligation; L4, adjacent neurons; L5, axotomized neurons.