Figure 3.

Candidate profiles from targeted analysis.

(A) The boxplots illustrate the protein targets with differential serum levels in patients with early stage (T1 and T2) melanoma without recurrence (N = 74) versus late stage (T3 and T4) melanoma patients that had a relapse during the time of follow-up (N = 34). These were detected by anti-RGN (HPA029104), anti-MTHFD1L (HPA029040) and anti-STX7 (HPA001467). Respective p-values are shown for each two-group comparison referring to the repeated analyses (Assay 1, 2 and 3). (B) The heat map visualize unsupervised hierarchical clustering of candidate profiles for the 108 patients in (A), showing three main clusters, of which one was enriched for late T-stage/relapsing (darker blue/gray colors) and the other two for early T-stage/non-relapsing (lighter blue/gray colors) patients respectively.