Table 1.
MIC50 of ETH in BCG and M. tuberculosis parental and mutant strains.
| Strain | INH | ETH | ISO | TAC |
|---|---|---|---|---|
| BCG | 0.38 | 15.86 | 3.93 | 0.76 |
| BCG ethA/R KO | 0.35 | NA | 3.85 | 5.91 |
| BCG ethA/R KO complement ethA/R | 0.39 | 14.49 | 4.04 | 0.27 |
| CDC1551 | 0.22 | 6.90 | 12.40 | 9.20 |
| CDC1551 ethA/R KO | 0.22 | 12.40 | 11.56 | 19.28 |
| CDC1551 ethA/R KO complement ethA/R | 0.20 | 4.77 | 14.00 | 6.42 |
| Erdman | 0.15 | 3.89 | 10.87 | 4.80 |
| Erdman ethA/R KO | 0.11 | 9.29 | 21.20 | 12.12 |
| Erdman ethA/R KO complement ethA/R | 0.12 | 3.25 | 13.75 | 2.07 |
| H37Rv | 0.20 | 3.30 | 13.08 | 2.0 |
| H37Rv ethA/R KO | 0.20 | 9.16 | 10.67 | 12.32 |
| H37Rv ethA/R KO complement ethA/R | 0.19 | 3.10 | 11.59 | 1.47 |
MIC50 concentrations are indicated in μM. NA, not available due to complete ETH resistance.