Table 1.
Thrombin generation and thrombin activity measurements in separate subgroups of patients
| Healthy volunteers (N = 10) | Cancer patients (N = 21) | AF patients (N = 20) | Hemophilia patients A (N = 15) | Cancer patients versus healthy volunteers t test p value | AF patients versus healthy volunteers t test p value | Hemophilia A patients versus healthy volunteers t test p value | Pearson r with thrombin activity (p value) (N = 17)a | |
|---|---|---|---|---|---|---|---|---|
| TG lag time (min), mean (SD) | 20.2 (3.9) | 13.27 (4.94) | 28.2 (9.5) | 38.57 (16.49) | <0.001 | 0.003 | 0.001 | −0.292 (0.255) |
| TG peak thrombin (nM), mean (SD) | 112.0 (58.7) | 272.79 (124.61) | 112.4 (107.1) | 27.65 (37.21) | <0.001 | 0.987 | 0.001 | 0.361 (0.155) |
| TG peak time (min), mean (SD) | 33.1 (6.1) | 19.05 (6.95) | 43.5 (17.7) | 41.43 (29.84) | <0.001 | 0.025 | 0.307 | −0.263 (0.309) |
| TG VI (nM/min), mean (SD) | 9.8 (6.7) | 58.13 (39.47) | 13.8 (16.1) | 1.76 (2.73) | <0.001 | 0.340 | 0.004 | 0.304 (0.235) |
| TG ETP (nM), mean (SD) | 2720.4 (924.2) | 2808.28 (660.31) | 2277.0 (1284.6) | 934.25 (1165.15) | 0.791 | 0.290 | <0.001 | 0.323 (0.206) |
| Prothrombin fragment 1 + 2 (pmol/l), mean (SD) | 110.4 (50.5) | 282.1 (103.9) | 123 (76.9) | 93.5 (25.9) | <0.001 | 0.645 | 0.280 | −0.051 (0.847) |
| Thrombin activity (mU/ml), mean (SD) | 0.00 | 0.47 (1.11) | 0.10 (0.34) | 0.20 (0.46) | 0.065 | 0.230 | 0.115 | 1 |
The correlation between parameters of the thrombin generation and thrombin activity is shown by the Pearson correlation coefficient, and means of the measurements are tested for equality by t test
AF atrial fibrillation, TG thrombin generation, VI velocity index, ETP endogenous thrombin potential
aOnly patients with nonzero thrombin activity