Table 2.
Association between IFNL genotypes and abnormally elevated serum iron indices
| IFNL genotype | Total n | Serum iron above normal | Serum ferritin above normal | ||||
|---|---|---|---|---|---|---|---|
| n (%) | OR (95 % CI) | P | n (%) | OR (95 % CI) | P | ||
| rs12979860 | |||||||
| TT | 39 | 28 (72) | 3.0 (1.4–6.6) | 0.005 | 20 (51) | 1.5 (0.7–3.3) | 0.27 |
| CC | 50 | 17 (34) | 0.5 (0.2–1.0) | 0.047 | 15 (30) | 0.7 (0.3–1.5) | 0.33 |
| rs8099917 | |||||||
| GG | 19 | 15 (79) | 4.5 (1.4–14.4) | 0.01 | 13 (68) | 4.1 (1.4–12.3) | 0.01 |
| TT | 95 | 42 (44) | 0.7 (0.4–1.3) | 0.33 | 35 (37) | 1.0 (0.5–1.8) | 0.91 |
| rs12980275 | |||||||
| GG | 33 | 22 (67) | 2.4 (1.1– 5.5) | 0.03 | 18 (54) | 2.3 (1.0–5.2) | 0.049 |
| AA | 56 | 20 (36) | 0.5 (0.2– 1.0) | 0.06 | 18 (32) | 0.8 (0.4–1.7) | 0.58 |
| rs12979860, rs8099917, rs12980275 | |||||||
| T, G, G | 95 | 52 (55) | 1.4 (0.8–2.6) | 0.21 | 39 (41) | 1.0 (0.5–1.9) | 0.98 |
| C, T, A | 151 | 65 (43) | 0.3 (0.1–0.7) | 0.003 | 55 (36) | 0.6 (0.3–1.3) | 0.18 |
| TT, GG, GG | 17 | 13 (76) | 3.9 (1.2–13.0) | 0.02 | 12 (71) | 4.9 (1.5–16.1) | 0.008 |
| CC, TT, AA | 49 | 17 (35) | 0.5 (0.3–1.1) | 0.08 | 14 (29) | 0.7 (0.3–1.4) | 0.30 |
P values for statistically significant differences between groups are shown in bold
Results of multivariate logistic regression analyses, adjusted for age and sex
OR odds ratio, CI confidence intervals