Figure 3.

Time course of cell-type specific cortical activity following transient thalamic inputs. The thalamic input is modeled as a single 10 msec wave of spikes starting at 400 msec. (A) Response of the refined single column with standard parameters responding to the transient thalamic inputs. Thalamic inputs are projected to both excitatory (E) and inhibitory (I) cells in layers 4 and 6. (B–D) show the same measure but with different external inputs. The non-default network values chosen are shown at the top of panels. These detailed simulations replicate our qualitative analysis (Figure 2) in which SST activation (B) or VIP inactivation (C) results in reduced responses, and VIP activation (D) results in prolonged responses.