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. 2017 Apr 25;8:485. doi: 10.3389/fimmu.2017.00485

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Copyright © 2017 Fu, Browne, Killick and Mulcahy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression patterns of the toll-like receptor (TLR) 3/4-associated subnetwork extracted from data representing chronic stage of Fasciola hepatica infection. Red and green nodes represent genes showing increased and decreased expression, respectively. The size of nodes is proportional to their betweenness centrality values. Several nodes that consistently presented in the TLR3/TLR4-associated subnetworks (generated from acute and chronic stages of infection, respectively) are highlighted with blue cycle.