Table 3.
The top 25 enriched Reactome pathways within the network at the chronic stage of ovine F. hepatica infection.
| Pathway | Total | Hits | P-value |
|---|---|---|---|
| MyD88:Mal cascade initiated on plasma membrane | 81 | 13 | 5.45E−11 |
| Toll-like receptor TLR1:TLR2 cascade | 81 | 13 | 5.45E−11 |
| Toll-like receptor TLR6:TLR2 cascade | 81 | 13 | 5.45E−11 |
| Toll-like receptor 2 (TLR2) cascade | 81 | 13 | 5.45E−11 |
| Activated TLR4 signaling | 100 | 14 | 6.33E−11 |
| Toll-like receptors cascades | 123 | 15 | 9.39E−11 |
| Toll-like receptor 4 (TLR4) cascade | 103 | 14 | 9.53E−11 |
| TRIF-mediated TLR3/TLR4 signaling | 87 | 13 | 1.39E−10 |
| MyD88-independent cascade | 88 | 13 | 1.61E−10 |
| Toll-like receptor 3 (TLR3) cascade | 88 | 13 | 1.61E−10 |
| Toll-like receptor 10 (TLR10) cascade | 74 | 11 | 4.26E−09 |
| Toll-like receptor 5 (TLR5) cascade | 74 | 11 | 4.26E−09 |
| MyD88 cascade initiated on plasma membrane | 74 | 11 | 4.26E−09 |
| Innate immune system | 521 | 26 | 4.73E−09 |
| TRAF6 (TNF receptor associated factor 6)-mediated induction of proinflammatory cytokines | 62 | 10 | 9.96E−09 |
| TRAF6-mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | 76 | 10 | 7.54E−08 |
| Toll-like receptor 7/8 (TLR7/8) cascade | 77 | 10 | 8.57E−08 |
| MyD88 dependent cascade initiated on endosome | 77 | 10 | 8.57E−08 |
| Toll-like receptor 9 (TLR9) cascade | 79 | 10 | 1.10E−07 |
| Immune system | 1140 | 37 | 1.40E−07 |
| TAK1 (also known as MAP3K7) activates NFkB by phosphorylation and activation of IKKs complex | 22 | 6 | 3.87E−07 |
| MAP kinase activation in TLR cascade | 55 | 8 | 7.44E−07 |
| TRAF6-mediated induction of TAK1 complex | 16 | 5 | 1.82E−06 |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | 20 | 5 | 6.18E−06 |
| Activation of the AP-1 family of transcription factors | 10 | 4 | 6.95E−06 |
The pathways are ranked by their raw P-values from functional enrichment analysis based on hypergeometric tests.