Table 2.
Secreted cytokine production following BCG stimulation in healthy children vs those with TB disease.
| Cytokine | Healthy median (IQR) pg/ml | Active TB disease median (IQR) pg/ml | p-Value |
|---|---|---|---|
| IL1β | 4,111 (1,056–4,118) | 1,479 (206–4,107) | 0.001 |
| IL17F | 1,283 (211–4,779) | 240 (26–1,543) | <0.0001 |
| IFNγ | 1,357 (180–2,379) | 186 (19–817) | <0.0001 |
| TNFα | 815 (270–21,848) | 380 (73–671) | <0.0001 |
| IL10 | 321 (101–615) | 586 (265–982) | 0.01 |
| IL6 | 26,914 (7,390–27,065) | 24,140 (9,673–28,354) | 0.1 |
| IL22 | 141 (60–337) | 158 (51–339) | 0.1 |
| IL23 | 74 (17–475) | 54 (0–242) | 0.09 |
| IL4 | 6.4 (2–19.3) | 5.9 (1–42.6) | 0.6 |
Median secreted cytokine levels (picograms per milliliter) with interquartile range for each group is shown. A Mann–Whitney test for all comparisons was performed, p-values are shown.