Fig. (1).

Overview of platelet surface receptors with their respective ligands (A) and the most important signaling pathways involved in platelet signaling (B). Abbreviations: AC, adenylate cyclase; cAMP, cyclic adenosylmonophosphate; CLEC-2, C-type lectin-like receptor 2; DAG, diacylglyceride; GAS6: growth arrest specific gene 6; IP, prostacyclin receptor; IP3, inositoltrisphosphate; MLCK, myosin light chain phosphatase kinase; MAPK, mitogen-activated protein kinase; PAR, protease-activated receptor; PLA2, phospholipase A2; SFK, sarcoma family kinase; TPa, thromboxane A2 receptor alpha; TXA2, thromboxane A2; vWF, von Willebrand factor.