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. 2017 Jan 17;3(3):484–499. doi: 10.1016/j.jcmgh.2017.01.002

Figure 5.

Figure 5

Effects of serotonin level and HSC activation on krasV12-induced liver fibrosis. Three-month-old adult zebrafish were treated with dox with or without serotonin, BW23C86, PCPA, and SB204741 for 7 days. (A) IF staining of collagen I antibody and quantification of fibrotic liver tissue area in collagen I antibody–stained liver sections (n > 8 in each group). (B) Staining and quantification of fibrotic liver tissue area in Picrosirius Red–stained liver sections (n > 8 in each group). (C) Staining and quantification of fibrotic liver tissue area in Gomori’s trichrome–stained liver sections (n > 8 in each group). *P < .05. Scale bars: (A) 50 μm, and (B and C) 500 μm. DAPI, 4′,6-diamidino-2-phenylindole.