Table 4.
Correlation between 2-arachidonoylglycerol (2AG) and metabolic parameters within overall premenopausal and menopausal cohorts and within body mass index classes. Data are shown as P values of the evaluated effects: non italic data show the effects of the metabolic parameters on 2AG levels; italic data show the BMI and menopause effects as well as their interactions (two-way ANCOVA; coefficients are reported in Supplemental Table 5).
| Metabolic parameter | Cohort | Overall | BMI classes |
Effect of BMIb |
||
|---|---|---|---|---|---|---|
| NW | OW | OB | P value | |||
| Waist circumference | Premenopausal | 0.253 (−) | 0.753 (−) | 0.508 (−) | 0.363 (−) | 0.541 (−) |
| Menopausal | 0.249 (+) | 0.624 (+) | 0.171 (+) | 0.957 (+) | 0.817 (−) | |
| Effect of MPa | 0.106 (+) | 0.563 (+) | 0.138 (+) | 0.522 (+) | 0.826 (+)c | |
| SBP | Premenopausal | 0.079 (+) | 0.174 (+) | 0.366 (+) | 0.360 (+) | 0.906 (−) |
| Menopausal | 0.546 (+) | 0.152 (+) | 0.517 (−) | 0.827 (+) | 0.507 (−) | |
| Effect of MPa | 0.386 (−) | 0.899 (+) | 0.267 (−) | 0.667 (−) | 0.674 (−)c | |
| DBP | Premenopausal | 0.179 (+) | 0.420 (+) | 0.706 (+) | 0.144 (+) | 0.493 (+) |
| Menopausal | 0.135 (+) | 0.094 (+) | 0.758 (+) | 0.646 (+) | 0.344 (−) | |
| Effect of MPa | 0.989 (−) | 0.346 (+) | 0.865 (−) | 0.476 (−) | 0.244 (−)c | |
| Glucose | Premenopausal | 0.624 (−) | 0.916 (−) | 0.538 (−) | 0.938 (+) | 0.897 (+) |
| Menopausal | 0.036 (+) | <0.001 (+) | 0.804 (+) | 0.538 (−) | 0.002 (−) | |
| Effect of MPa | 0.109 (+) | 0.005 (+) | 0.507 (+) | 0.628 (−) | 0.022 (−)c | |
| Insulin | Premenopausal | 0.285 (+) | 0.280 (−) | 0.225 (+) | 0.347 (+) | 0.172 (+) |
| Menopausal | 0.197 (+) | 0.274 (+) | 0.357 (+) | 0.753 (+) | 0.637 (−) | |
| Effect of MPa | 0.815 (+) | 0.138 (+) | 0.685 (−) | 0.735 (−) | 0.241 (−)c | |
| HOMA-IR | Premenopausal | 0.377 (+) | 0.410 (−) | 0.354 (+) | 0.377 (+) | 0.236 (+) |
| Menopausal | 0.099 (+) | 0.035 (+) | 0.381 (+) | 0.953 (+) | 0.189 (−) | |
| Effect of MPa | 0.581 (+) | 0.027 (+) | 0.821 (−) | 0.584 (−) | 0.078 (−)c | |
| Total cholesterol | Premenopausal | 0.084 (+) | 0.530 (+) | 0.807 (+) | 0.040 (+) | 0.135 (+) |
| Menopausal | 0.087 (+) | 0.006 (+) | 0.137 (+) | 0.523 (−) | 0.037 (−) | |
| Effect of MPa | 0.707 (+) | 0.036 (+) | 0.323 (+) | 0.089 (−) | 0.011 (−)c | |
| HDL-cholesterol | Premenopausal | 0.887 (−) | 0.484 (+) | 0.772 (−) | 0.721 (−) | 0.466 (−) |
| Menopausal | 0.565 (+) | 0.439 (+) | 0.736 (+) | 0.915 (−) | 0.530 (−) | |
| Effect of MPa | 0.627 (+) | 0.773 (+) | 0.689 (+) | 0.901 (+) | 0.911 (−)c | |
| Triglycerides | Premenopausal | 0.006 (+) | 0.117 (+) | 0.265 (+) | 0.020 (+) | 0.415 (+) |
| Menopausal | 0.005 (+) | 0.001 (+) | 0.034 (+) | 0.415 (+) | 0.486 (−) | |
| Effect of MPa | 0.631 (+) | 0.161 (+) | 0.762 (+) | 0.710 (−) | 0.308 (−)c | |
BMI: body mass index; NW: normal weight; OW: overweight; OB: obese; MP: menopause; SBP: systolic blood pressure; DBP: diastolic blood pressure; HOMA-IR: homeostatic model assessment – insulin resistance; HDL: high density lipoprotein.
Effect of MP on the association between 2AG levels and metabolic parameters within BMI classes. Positive effect (+): the positive (or negative) association found in menopausal women is higher (or lower) than in premenopausal women; negative effect (−): the positive (negative) association found in menopausal women is lower (or higher) than in premenopausal women.
Effect of BMI on the association between 2AG levels and metabolic parameters within premenopausal and menopausal cohorts. Positive effect (+): the positive (or negative) correlation found within the premenopausal/menopausal cohort increased (or decreased) with increasing BMI classes; negative effect (−): the positive (or negative) correlation within the premenopausal/menopausal cohort decreased (or increased) with increasing BMI classes.
Interaction between BMI and MP effects on the correlation between 2AG levels and metabolic parameters. $ Positive interaction (+): the negative effect of BMI in menopausal is lower than in premenopausal females (i.e., the higher values in menopausal than in premenopausal females increased with BMI); negative interaction (−): the negative effect of BMI in menopausal is lower than in premenopausal females (i.e., the higher values in menopausal than in premenopausal females decreased with BMI).