Table 2. Univariate and multi-variable analysis of survival and leukemic transformation in 261 ‘young' adults with chronic myelomonocytic leukemia.

Variable	Censor survival univariate	Censor survival multivariate	Censor transplant univariate	Censor transplant multivariate	Censor leukemic transformation univariate	Censor leukemic transformation multivariate
Older age	0.99	—	0.89	—	0.1	—
Males	0.5	—	0.8	—	0.5	—
Lower hemoglobin g/dl	<0.0001	0.01	<0.0001	0.01	<0.0001	—
Higher WBC × 109/l	0.002	—	0.0002	—	0.2	—
Higher ANC × 109/l	0.005	—	0.001	—	0.7	—
Higher AMC × 109/l)	0.02	—	0.0004	—	0.01	—
Higher ALC × 109/l	0.9	—	0.3	—	0.07	—
Lower platelets × 109/l	0.004	0.03	0.2	—	0.1	—
Higher PB blast %	<0.0001	0.001	<0.0001	0.002	<0.0001	<0.0001
Higher BM blast %	0.007	—	0.02	—	<0.0001	0.0007
Presence of circulating immature myeloid cells	0.007	—	<0.0001	—	<0.0001	0.0002
ASXL1 mutations	0.06	—	0.003	0.007	0.8	—
SETBP1 mutations	0.07	—	0.05	—	0.4	—
SF3B1	0.5	—	0.2		0.7	—
SRSF2	0.03	0.04	0.04	0.008	0.7	—
U2AF1	0.2	—	0.5	—	—	—
Mayo-French cytogenetic risk stratification	<0.0001	HOLDS for high risk 0.02	<0.0001	0.04	<0.0001	—
Spanish cytogenetic risk stratification;	<0.0001	—	0.0002	—	<0.0001	—

Abbreviations: ALC, absolute lymphocyte count; AMC, absolute monocyte count; ANC, absolute neutrophil count; ASXL1, additional sex combs 1 gene; BM, bone marrow; PB, peripheral blood; SETBP1, SET binding protein 1; SF3B1, splicing factor 3B, subunit 1; SRSF2, serine/arginine-rich splicing factor 2; U2AF1, U2 small nuclear RNA auxiliary factor 1; WBC, white blood cell count.

Mayo-French cytogenetic risk stratification; Low risk, normal karyotype, −Y and sole der (3q), High risk, complex and monosomal karyotype, Intermediate all other karyotype abnormalities, Spanish cytogenetic risk stratification; Low risk, −Y and normal karyotype, High risk, +8, −chromosome 7abnormalities and complex karyotype, Intermediate risk, all other abnormalities. Bold entries signify statistically significant P-values (i.e. P<0.05).