Table 2. Comparison of outcomes between traditional meta-analysis and Bayesian network meta-analysis.
| Treatment Comparisons | Results of Pair-Wise Meta-Analysis | I2 (%) | Results of Network Meta-Analysis |
|---|---|---|---|
| Clinical remission | |||
| Budesonide ≥4 mg/d v placebo | 2.72 (1.86, 3.99) | 24.6 | 2.88 (1.99, 4.26) |
| 5-ASA 4 g/d v BDP 3 mg/d | 0.74 (0.13, 4.02) | 79.1 | 1.00 (0.58, 1.63) |
| 5-ASA 4 g/d v 5-ASA 1.5 to 2.0 g/d + BDP 3 mg/d | 0.21 (0.06, 0.84) | — | 0.39 (0.05, 1.11) |
| BDP 3 mg/d v 5-ASA 1.5 to 2.0 g/d + BDP 3 mg/d | 0.73 (0.15, 3.49) | — | 0.40 (0.06, 1.26) |
| 5-ASA 1 g/d v placebo | 6.22 (3.86, 10.01) | 0 | 5.57 (3.70, 8.23) |
| 5-ASA 4 g/d v Budesonide 2 to 2.3 mg/d | 1.95 (1.06, 3.60) | — | 2.84 (1.78, 4.17) |
| 5-ASA 1.5 to 2.0 g/d v 5-ASA 1 g/d | 1.11 (0.77, 1.61) | 0 | 1.15 (0.79, 1.61) |
| 5-ASA 1.5 to 2.0 g/d v BDP 3 mg/d | 1.27 (0.50, 3.22) | — | 1.00 (0.58, 1.64) |
| 5-ASA 1 g/d v BDP 3 mg/d | 0.71 (0.38, 1.33) | — | 0.88 (0.51, 1.39) |
| Budesonide 2 to 2.3 mg/d v Betamethasone 5 mg/d | 0.16 (0.04, 0.73) | — | 0.42 (0.16, 0.88) |
| Budesonide 2 to 2.3 mg/d v Hydrocortisone 100 mg/d | 1.04 (0.63, 1.71) | — | 1.42 (0.75, 2.59) |
| 5-ASA 4 g/d v 5-ASA 1.5 to 2.0 g/d | 1.06 (0.72, 1.58) | 0 | 1.02 (0.68, 1.45) |
| Budesonide≥ 4 mg/d v Budesonide 2 to 2.3 mg/d | 1.50 (0.92, 2.46) | 0 | 1.30 (0.80, 1.98) |
| 5-ASA 1.5 to 2.0 g/d v placebo | 7.11 (3.48, 14.52) | 53.8 | 6.30 (4.33, 9.08) |
| Budesonide 0.5 mg/d v placebo | 2.00 (0.87, 4.63) | — | 1.65 (0.69, 3.17) |
| Budesonide 2 to 2.3 mg/d v placebo | 2.79 (1.22, 6.37) | — | 2.30 (1.50, 3.47) |
| Budesonide 2 to 2.3 mg/d v Budesonide 0.5 mg/d | 1.39 (0.65, 3.00) | — | 1.64 (0.71, 3.29) |
| Budesonide ≥4 mg/d v Budesonide 0.5 mg/d | 2.44 (1.16, 5.17) | — | 2.06 (0.90, 4.12) |
| 5-ASA 4 g/d v placebo | 5.62 (3.28, 9.65) | 23.9 | 6.35 (4.33, 9.26) |
| 5-ASA 4 g/d v 5-ASA 1 g/d | 1.03 (0.58, 1.81) | 0 | 1.16 (0.77, 1.71) |
| BDP 3 mg/d v Prednisolone ≥30 mg/d | 0.90 (0.45, 1.78) | — | 1.16 (0.54, 2.24) |
| 5-ASA 1.5 to 2.0 g/d v Prednisolone 20 to 25 mg/d | 2.47 (1.53, 3.97) | — | 2.30 (1.37, 3.62) |
| 5-ASA 1 g/d v Budesonide 2 to 2.3 mg/d | 2.43 (1.05, 5.61) | — | 2.50 (1.58, 3.98) |
| Budesonide 2 to 2.3 mg/d v Prednisolone ≥30 mg/d | 0.60 (0.22, 1.65) | — | 0.41 (0.18, 0.84) |
| Budesonide 2 to 2.3 mg/d v Prednisolone 20 to 25 mg/d | 1.10 (0.47, 2.61) | — | 0.84 (0.46, 1.36) |
| 5-ASA 1 g/d v Hydrocortisone 356 mg/d | 1.36 (0.55, 3.40) | — | 1.61 (0.48, 3.91) |
| 5-ASA 1 g/d v Prednisolone 20 to 25 mg/d | 1.68 (0.78, 3.62) | — | 2.04 (1.22, 3.23) |
| 5-ASA 4 g/d v Hydrocortisone 100 mg/d | 10.25 (2.73, 38.45) | — | 4.00 (1.99, 7.59) |
| Betamethasone 5 mg/d v Prednisolone 20 to 25 mg/d | 1.47 (0.66, 3.31) | — | 2.30 (0.96, 4.66) |
| Endoscopic remission | |||
| Budesonide ≥4 mg/d v placebo | 2.29 (1.42, 3.71) | 51.6 | 2.55 (1.55, 4.12) |
| 5-ASA 4 g/d v BDP 3 mg/d | 1.22 (0.51, 2.94) | — | 1.27 (0.60, 2.51) |
| 5-ASA 4 g/d v 5-ASA 1.5 to 2.0 g/d + BDP 3 mg/d | 0.60 (0.24, 1.46) | — | 0.72 (0.44, 1.13) |
| BDP 3 mg/d v 5-ASA 1.5 to 2.0 g/d + BDP 3 mg/d | 0.55 (0.26, 1.17) | 0 | 0.63 (0.30, 1.17) |
| 5-ASA 1 g/d v placebo | 6.45 (4.23, 9.82) | 0 | 4.97 (3.21, 7.51) |
| 5-ASA 4 g/d v Budesonide 2 to 2.3 mg/d | 1.19 (0.66, 2.16) | — | 1.60 (0.89, 2.66) |
| 5-ASA 1.5 to 2.0 g/d v 5-ASA 1 g/d | 1.24 (0.86, 1.78) | 0 | 1.01 (0.64, 1.48) |
| 5-ASA 4 g/d v 5-ASA 1.5 to 2.0 g/d | 1.08 (0.73, 1.61) | 0 | 1.12 (0.68, 1.73) |
| 5-ASA 1.5 to 2.0 g/d v placebo | 4.49 (2.61, 7.73) | 26.3 | 4.89 (3.22, 7.16) |
| Budesonide 0.5 mg/d v placebo | 1.36 (0.52, 3.56) | — | 1.23 (0.39, 2.98) |
| Budesonide 2 to 2.3 mg/d v placebo | 3.15 (1.29, 7.70) | — | 3.53 (1.90, 5.95) |
| Budesonide 2 to 2.3 mg/d v Budesonide 0.5 mg/d | 2.32 (0.99, 5.46) | — | 3.57 (1.20, 8.89) |
| Budesonide ≥4 mg/d v Budesonide 0.5 mg/d | 3.42 (1.49, 7.86) | — | 2.58 (0.91, 5.92) |
| Budesonide ≥4 mg/d v Budesonide 2 to 2.3 mg/d | 1.47 (0.70, 3.11) | — | 0.77 (0.37, 1.48) |
| 5-ASA 4 g/d v placebo | 6.86 (3.53, 13.34) | 0 | 5.36 (3.26, 8.38) |
| 5-ASA 4 g/d v 5-ASA 1 g/d | 1.34 (0.76, 2.36) | 0 | 1.11 (0.65, 1.76) |
| BDP 3 mg/d v Prednisolone ≥30 mg/d | 1.21 (0.60, 2.46) | — | 1.58 (0.68, 3.36) |
| 5-ASA 1.5 to 2.0 g/d v 5-ASA 1.5 to 2.0 g/d + BDP 3 mg/d | 0.18 (0.03, 1.02) | — | 0.66 (0.44, 0.97) |
| 5-ASA 1.5 to 2.0 g/d v BDP 3 mg/d | 0.25 (0.04, 1.40) | — | 1.17 (0.54, 2.16) |
| 5-ASA 1.5 to 2.0 g/d v Prednisolone 20 to 25 mg/d | 1.47 (0.91, 2.38) | — | 1.40 (0.74, 2.34) |
| 5-ASA 1 g/d v Budesonide 2 to 2.3 mg/d | 0.95 (0.28, 3.20) | — | 1.50 (0.81, 2.59) |
| Budesonide 2 to 2.3 mg/d v Prednisolone ≥30 mg/d | 1.33 (0.22, 7.93) | 83.1 | 1.20 (0.58, 2.22) |
| Budesonide 2 to 2.3 mg/d v Prednisolone 20 to 25 mg/d | 0.71 (0.22, 2.25) | — | 1.01 (0.49, 1.86) |
| 5-ASA 1 g/d v Prednisolone 20 to 25 mg/d | 1.36 (0.65, 2.86) | — | 1.43 (0.74, 2.42) |
| 5-ASA 4 g/d v Hydrocortisone 100 mg/d | 11.29 (3.02, 42.28) | — | 3.49 (0.91, 9.87) |
| Histopathological remission | |||
| 5-ASA 4 g/d v Budesonide 2 to 2.3 mg/d | 1.25 (0.72, 2.17) | — | 1.67 (0.79, 3.41) |
| 5-ASA 1.5 to 2.0 g/d v 5-ASA 1 g/d | 1.45 (1.01, 2.07) | 0 | 1.42 (0.78, 2.26) |
| 5-ASA 4 g/d v 5-ASA 1 g/d | 1.51 (0.86, 2.64) | 0 | 1.44 (0.72, 2.66) |
| 5-ASA 1 g/d v placebo | 4.36 (1.82, 10.42) | 14.9 | 6.33 (2.67, 13.32) |
| 5-ASA 4 g/d v 5-ASA 1.5 to 2.0 g/d | 1.15 (0.66, 1.99) | 0 | 1.05 (0.52, 1.90) |
| 5-ASA 1.5 to 2.0 g/d v placebo | 5.75 (2.11, 15.70) | 31 | 8.56 (3.79, 17.29) |
| 5-ASA 4 g/d v placebo | 9.49 (2.14, 42.04) | 32.7 | 8.64 (3.68, 20.26) |
| 5-ASA 1.5 to 2.0 g/d v Prednisolone 20 to 25 mg/d | 1.36 (0.80, 2.33) | — | 1.50 (0.62, 3.18) |
| 5-ASA 1 g/d v Budesonide 2 to 2.3 mg/d | 1.80 (0.55, 5.90) | — | 1.26 (0.50, 2.84) |
| Budesonide 2 to 2.3 mg/d v Prednisolone ≥30 mg/d | 0.57 (0.16, 2.04) | — | 0.75 (0.11, 2.40) |
| Budesonide 2 to 2.3 mg/d v Prednisolone 20 to 25 mg/d | 0.81 (0.23, 2.89) | — | 1.00 (0.32, 2.25) |
| Adverse events | |||
| Budesonide ≥4 mg/d v placebo | 1.50 (1.10, 2.05) | 0 | 1.56 (0.84, 2.69) |
| 5-ASA 1 g/d v placebo | 0.96 (0.39, 2.37) | 0 | 1.31 (0.59, 2.57) |
| 5-ASA 4 g/d v Budesonide 2 to 2.3 mg/d | 0.80 (0.46, 1.41) | — | 0.73 (0.35, 1.32) |
| 5-ASA 1.5 to 2.0 g/d v 5-ASA 1 g/d | 1.15 (0.70, 1.87) | — | 1.05 (0.54, 1.66) |
| 5-ASA 1.5 to 2.0 g/d v BDP 3 mg/d | 0.68 (0.31, 1.48) | 0 | 0.91 (0.41, 1.75) |
| 5-ASA 1 g/d v BDP 3 mg/d | 1.19 (0.52, 2.75) | — | 0.91 (0.38, 1.82) |
| Budesonide 2 to 2.3 mg/d v Betamethasone 5 mg/d | 0.60 (0.16, 2.28) | — | 1.02 (0.29, 2.75) |
| Budesonide 2 to 2.3 mg/d v Hydrocortisone 100 mg/d | 0.67 (0.39, 1.13) | — | 0.64 (0.24, 1.25) |
| 5-ASA 4 g/d v 5-ASA 1.5 to 2.0 g/d | 0.24 (0.08, 0.76) | — | 0.74 (0.30, 1.43) |
| Budesonide ≥4 mg/d v Budesonide 2 to 2.3 mg/d | 1.24 (0.75, 2.07) | 0 | 1.31 (0.69, 2.29) |
| 5-ASA 1.5 to 2.0 g/d v placebo | 0.52 (0.18, 1.53) | — | 1.30 (0.59, 2.34) |
| Budesonide 0.5 mg/d v placebo | 1.36 (0.63, 2.94) | — | 1.46 (0.59, 3.31) |
| Budesonide 2 to 2.3 mg/d v placebo | 1.30 (0.60, 2.82) | — | 1.25 (0.63, 2.08) |
| Budesonide 2 to 2.3 mg/d v Budesonide 0.5 mg/d | 0.95 (0.44, 2.05) | — | 1.01 (0.36, 2.14) |
| Budesonide ≥4 mg/d v Budesonide 0.5 mg/d | 1.14 (0.54, 2.41) | — | 1.25 (0.45, 2.69) |
| BDP 3 mg/d v Prednisolone ≥30 mg/d | 1.28 (0.42, 3.87) | — | 1.35 (0.40, 3.84) |
| BDP 3 mg/d v 5-ASA 1.5 to 2.0 g/d + BDP 3 mg/d | 0.72 (0.18, 2.93) | — | 0.83 (0.15, 2.80) |
| 5-ASA 1.5 to 2.0 g/d v 5-ASA 1.5 to 2.0 g/d + BDP 3 mg/d | 0.51 (0.12, 2.19) | — | 0.72 (0.13, 2.23) |
| 5-ASA 1.5 to 2.0 g/d v Prednisolone 20 to 25 mg/d | 1.49 (0.93, 2.40) | — | 1.72 (0.77, 3.33) |
| 5-ASA 1 g/d v Budesonide 2 to 2.3 mg/d | 0.31 (0.03, 3.12) | — | 1.12 (0.46, 2.42) |
| Budesonide 2 to 2.3 mg/d v Prednisolone ≥30 mg/d | 0.85 (0.07, 10.07) | 38.4 | 1.15 (0.27, 3.29) |
| Budesonide 2 to 2.3 mg/d v Prednisolone 20 to 25 mg/d | — | — | 1.76 (0.61, 4.02) |
| 5-ASA 1 g/d v Hydrocortisone 356 mg/d | 0.91 (0.27, 3.13) | — | 1.23 (0.23, 4.11) |
| 5-ASA 4 g/d v placebo | 0.81 (0.31, 2.07) | — | 0.88 (0.42, 1.53) |
| 5-ASA 1 g/d v Prednisolone 20 to 25 mg/d | 2.53 (0.89, 7.16) | — | 1.73 (0.75, 3.49) |
| 5-ASA 4 g/d v Hydrocortisone 100 mg/d | 0.18 (0.01, 3.91) | — | 0.47 (0.13, 1.07) |
| Betamethasone 5 mg/d v Prednisolone 20 to 25 mg/d | 1.27 (0.40, 4.08) | — | 2.13 (0.61, 5.80) |
5-ASA, 5-aminosalicylic acid; BDP, beclomethasone dipropionate.