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. 2017 Apr 24;17:48. doi: 10.1186/s12935-017-0418-6

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Metformin may regulate HCC cells proliferation, migration and invasion after insufficient RFA by promoting AMPK/PTEN/Akt pathway. Metformin was used to treat HepG2 cells, and western blot was used to determined the expression of p-AMPK, PTEN, p-Akt, E-cadherin, PCNA and VEGF