Table 3.
Frequency and severity of adverse drug reactions among study patients
| Grade - N (%) | ||||||
|---|---|---|---|---|---|---|
| ADRs | 1 | 2 | 3 | 4 | Patients with ADRs | |
| Haematological | Anaemia | 29 (49.2) | 16 (27.1) | 3 (5.1) | 0 (0.0) | 48 (81.4) |
| Leukopenia | 12 (20.3) | 9 (15.3) | 1 (1.7) | 2 (3.4) | 24 (40.7) | |
| Neutropenia | 7 (11.8) | 4 (6.8) | 4 (6.8) | 2 (3.4) | 17 (28.8) | |
| Lymphopenia | 8 (13.6) | 23 (39.0) | 13 (22.0) | 2 (3.4) | 46 (78.0) | |
| Thrombocytopenia | 11 (18.6) | 0 (0.0) | 0 (0.0) | 1 (1.7) | 12 (20.3) | |
| Renal | Increase in serum creatinine | 11 (19.0) | 5 (8.6) | 0 (0.0) | 0 (0.0) | 17 (27.6) |
| Reduction in creatinine clearance | 14 (24.6) | 20 (35.1) | 2 (3.5) | 0 (0.0) | 36 (63.2) | |
| Gastrointestinal | Nausea | 13 (22.0) | 18 (30.5) | 7 (11.9) | - | 38 (64.4) |
| Vomiting | 11 (18.6) | 9 (15.3) | 8 (13.6) | 0 (0.0) | 28 (47.5) | |
| Diarrhoea | 5 (8.5) | 2 (3.4) | 1 (1.7) | 0 (0.0) | 8 (13.6) | |
ADRs Adverse Drug Reactions, N absolute number of patients