Table 4.
Relationship between ADRs and cisplatin excretion in urine
| Cisplatin excretion | ||||||
|---|---|---|---|---|---|---|
| 0–12 h | 12–24 h | 24–48 h | ||||
| SCT (R/p value) | ULiR (p value) | SCT (R/p value) | ULiR (p value) | SCT (R/p value) | ULiR (p value) | |
| Number variation (range) | ||||||
| Haemoglobin | 0.000/1.000 | 0.7375 | 0.047/0.737 | 0.7835 | 0.024/0.867 | 0.0609 |
| Leukocytes | 0.101/0.471 | 0.4833 | 0.256/0.064 | 0.1695 | 0.162/0.247 | 0.1122 |
| Neutrophils | 0.125/0.372 | 0.4689 | 0.237/0.088 | 0.0969 | 0.183/0.190 | 0.0740 |
| Lymphocytes | 0.071/0.613 | 0.2391 | 0.118/0.401 | 0.9156 | 0.073/0.605 | 0.1955 |
| Platelets | −0.170/0.223 | 0.3899 | 0.063/0.653 | 0.6527 | −0.350/0.806 | 0.9802 |
| Creatinine | −0.055/0.698 | 0.7700 | 0.105/0.459 | 0.5176 | 0.290/0.037 | 0.3827 |
| Creatinine clearance | 0.009/0.951 | 0.9380 | 0.096/0.496 | 0.7957 | 0.259/0.063 | 0.3884 |
| SCT (R/p value) | ULoR (p value) | SCT (R/p value) | ULoR (p value) | SCT (R/p value) | ULoR (p value) | |
| Severity by grade | ||||||
| Anaemia | 0.073/0.601 | 0.3811 | 0.141/0.315 | 0.4889 | 0.025/0.858 | 0.3717 |
| Leukopenia | 0.041/0.771 | 0.8971 | −0.039/0.784 | 0.5143 | 0.061/0.663 | 0.7397 |
| Neutropenia | −0.007/0.960 | 0.9863 | −0.067/0.632 | 0.3471 | 0.047/0.741 | 0.7066 |
| Lymphopenia | 0.071/0.613 | 0.4500 | 0.118/0.401 | 0.2684 | 0.073/0.605 | 0.7810 |
| Thrombocytopenia | 0.038/0.786 | 0.3511 | −0.067/0.631 | 0.2847 | −0.020/0.889 | 0.4774 |
| Increase in serum creatinine | −0.069/0.627 | 0.6263 | 0.200/0.155 | 0.9527 | 0.325/0.019 | 0.1462 |
| Reduction in creatinine clearance | −0.100/0.483 | 0.4715 | 0.249/0.078 | 0.9217 | 0.276/0.050 | 0.7730 |
| Nausea | −0.065/0.642 | 0.6791 | −0.124/0.377 | 0.5203 | 0.009/0.949 | 0.7742 |
| Vomiting | −0.101/0.471 | 0.4140 | −0.154/0.270 | 0.7819 | −0.024/0.866 | 0.9087 |
| Diarrhoea | −0.195/0.161 | 0.1685 | −0.103/0.463 | 0.3765 | −0.044/0.754 | 0.6894 |
SCT Spearman Correlation test, R correlation coefficient, ULiR Univariate Linear Regression, ULoR Univariate Logistic Regression. For ULoR, p values were only showed, because all values were > 0.05, odds ratio and 95% confidence intervals were not showed; anaemia, grade 0 versus grade 1 versus grades 2 + 3; leukopenia, neutropenia and thrombocytopenia, grade 0 versus grades 1 + 2 + 3 + 4; lymphopenia, grades 0 + 1 versus grade 2 versus grades 3 + 4; increase in serum creatinine, grade 0 versus grades 1 + 2; reduction in creatinine clearance, grade 0 versus grade 1 versus grades 2 + 3; nausea and vomiting, grade 0 versus grade 1 versus grades 2 + 3; diarrhoea, grade 0 versus grades 1 + 2 + 3