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. Author manuscript; available in PMC: 2018 Apr 6.
Published in final edited form as: Ann Neurol. 2017 Apr 6;81(4):583–596. doi: 10.1002/ana.24910

Figure 1. Tau deposition locally associated with hypometabolism in the temporal lobe.

Figure 1

A. Mean SUVR maps for Flortaucipir (FTP) and Fluorodeoxyglucose (FDG) across the 90 study participants.

B. Left: Local correlation map between FTP and FDG, adjusting for age. Temporal tau deposition is locally associated with FDG hypometabolism. Right: Interaction effect of global continuous PiB on the local FTP-FDG association, adjusting for age. FTP-associated temporal hypometabolism is dependent on PiB levels.

C. Local FTP-associated hypometabolism is only observed in the high-PiB participants.

Scale: cold colors represent hypometabolism. Threshold: T<−2·65, p<0·010. Arrows indicate peak statistics.