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PI3K3CA mutation may predict synergism of combination of ARQ 092 and ARQ 087. Somatic mutation analysis was performed for 45 cancer cell lines tested. Synergistic effect of ARQ 092 and ARQ 087 combination was defined as CI<0.85. (a) Scatter plot shows the correlation between synergism and PIK3CA and PIK3R1 mutations. (b) Scatter plot shows the correlation between synergism and Ras mutations. CI, Combination Index; WT, wild type.
