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. 2017 Feb 28;28(5):503–513. doi: 10.1097/CAD.0000000000000486

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Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/

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Fig. 5 — Combination of ARQ 092 and ARQ 087 enhanced the inhibition of the AKT and FGFR pathways in vivo. (a) Tumor samples from AN3CA bearing mice treated with ARQ 092 at 100 mg/kg or ARQ 087 at 75 mg/kg or combined treatment were assessed for pFGFR (Y653/Y654), FGFR2, pAKT (S473), AKT, pPRAS40 (T246), pS6 (S235/S236), and pS6 (S240/S244) using western blot analysis. Six samples from each group were analyzed. One of the samples from vehicle was not analyzed due to poor quality. (b) Plasma and tumor levels for both compounds in single agent and combination dose groups.