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. 2017 Apr 24;48(5):1262–1270. doi: 10.1161/STROKEAHA.116.014321

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© 2017 The Authors.

Stroke is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 2. — Analysis of the effect of Actovegin and placebo on Alzheimer’s Disease Assessment Scale, cognitive subscale, extended version (ADAS-cog+). A, Change in ADAS-cog+ score from baseline over the course of the study in the intent-to-treat (ITT) population. B, Analysis of ADAS-cog+ responders in the ITT population. A responder was defined as demonstrating an improvement of ≥4 points on the ADAS-cog+ scale using observed case data. *P=0.005; †P<0.001; ‡P<0.05 vs placebo. CI indicates confidence interval; LS, least squares; and tx, treatment.